lidocaine HCl Injection, USP (Xylocaine®) Levofloxacin in 5% Dextrose Injection Lidocaine Hydrochloride Injection, USP
Find patient medical information for Buffered Lidocaine Injection on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Jul 01, 1992 · The purpose of this study was to compare the pain of infiltration between unbuffered lidocaine and buffered lidocaine in a traumatic laceration. Solutions of unbuffered 1% lidocaine and buffered 1% lidocaine were randomly assigned to Site I or Site II of a single laceration for each subject, with the patient serving as self-control. OBJECTIVES: To determine the physical compatibility and chemical stability of lidocaine hydrochloride solution buffered with 8.4% sodium bicarbonate, with and without epinephrine, packaged in polypropylene syringes and stored at 5°C with protection from light. To Buffer or Not To Buffer – Theory: •Lidocaine HCl is acidic (required for stability) –1% lidocaine: pH = 6.1 1 –1% lido w epi: pH = 4.21 –Injecting acid causes pain •Lidocaine HCl is primarily in ionized form in solution –Buffering with NaHCO3 creates more non-ionized molecules – needed for entry into neurons 1 Frank, SG, et al.
The solution contains no bacteriostat, antimicrobial agent or added buffer and is intended only for single-use. pH is adjusted with carbon dioxide. Per the USP monograph for Sodium Bicarbonate Inj., pH is between 7.0 and 8.5. Osmolar concentration is 2 mOsmol/mL (calc.). Sodium bicarbonate, 84 mg is equal to one milliequivalent each of Na+ and
Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes. Can J Hosp Pharm 2009 ; 62, 5: 375-380. 3263 Revue Donnelly R.F. Stability of buffered lidocaine in glass vials. Can J Hosp Pharm 2011 ; 64, 4: 289-290. 3420 Revue El Kateb N, Chaussard M, Bellenger P, Petit A, Faure P. Skip to main content. MENU
Reduced pain on injection of lidocaine and epinephrine buffered to a neutral pH was confirmed in 20 subjects (P < .01). Concentrations of buffered lidocaine and epinephrine were performed in order to evaluate their stability. Buffered lidocaine dropped to 66.1% of initial concentrations after 4 weeks when stored at 25°C.
Abstract: The stability of 20 mg/mL lidocaine hydrochloride injection in 12-mL polypropylene syringes stored at ambient temperature and at 4°C for up to 90 days was investigated. A highperformance liquid chromatographic stability-indicating assay was used to determine the concentration level of lidocaine hydrochloride injection at 0, 1, 4, 7